Inbriz, an industrial hemp and electronic cigarette chain company, announces it raised ten million RMB in angel round financing. Investors are Kaijie Capital and Zeyi Capital.
Looking at the information of industry and commerce, we can see that Inbriz headquarters is in Shenzhen. Its predecessor is Pingyuan Intelligent Agricultural Technology. In April 2019, its name was changed to Shenzhen Inbriz(Xianhuo) Technology Co., Ltd.
According to the person in charge, Inbriz has set up an overseas structure and plans to launch an IPO in the United States or Canada as early as 2021. In the upper and middle industrial chains, Inbriz has reached strategic cooperation with many industrial hemp companies at home and abroad. In addition, Inbriz also participates in the integration of planting, plant extraction, product development and other industrial chains in order to control the quality of raw materials.
In the end products, Inbriz brand electronic cigarettes have been marketed. Inbriz CBD brand skin care products using CBD (cannabis bisphenol) ingredients will be launched in China soon. In terms of foreign trade distribution, Inbriz plans to supply electronic cigarettes and consumer raw materials mainly consisting of CBD, industrial cannabis broad-spectrum oil, CBD vapes.
Demetrix, a hemp technology company, has completed a $50 million A round of financing for cannabinoid biosynthesis. Tuatara Capital led the round, and seed round investor Horizons Ventures also participated.
Horizons Ventures, as Li Ka-shing’s personal investment agency, has invested in Facebook, Skype, and in recent years has bet on artificial meat, encrypted assets and other frontier areas, investing in Zoom, Impossible Food, Bakkt, Slack and other companies.
What’s Demetrix’s background, what’s its advantage, why is it favored by Li Ka-shing’s personal investment institutions and participated in investment twice?
Key Technologies: Cannabinoid Synthesis by Yeast
Demetrix’s most interesting technology is cannabinoid synthesis by yeast. This technology is very similar to beer fermentation, but it uses genetically modified yeast cells to ferment cannabinoid.
But Demetrix is not the sole producer of cannabinoid synthesized by yeast. Several companies are involved, such as CB Therapeutics and Hyasynth Bio, a Canadian startup, to enter the cannabinoid synthesis market, and Intrexon Corporation and Surterra Wellness to co-invest. InMed Pharmaceutical Co. is also actively engaged in the biosynthetic cannabinoid project to promote commercial production of fermented cannabinoid based on $100 million.
Demetrix’s advantage is that Demetrix can obtain the exclusive license of its founder Jay Keasling’s research team in Berkeley, which is its absolute competitive advantage.
Key person: Jay Keasling
Jay Keasling, founder of the company and professor of chemical engineering and bioengineering at the University of California, Berkeley, is currently focusing on the development of Engineering Chemistry and genetic tools within microorganisms and one of the most important authorities in synthetic biology.
On February 27, 2019, Nature published a research paper on the chemical synthesis of cannabinoids and their unnaturalanalogues in yeast by enzymes, namely Complete biosynthesis of cannabinoids and their unnaturalanaloguesin yeast. Using galactose as raw material, heterologous reconstruction of cannabinoids biosynthesis pathway was completed in Saccharomyces cerevisiae, including cannabis. Biosynthesis of terpenoid phenolic acid (CBGA), tetrahydrocannabinol (THCA), cannabinol (CBDA) and their derivatives. Professor Jay Keasling, Ph.D. Hou Luo Xiaozhou of the Institute of Quantitative Biological Sciences, University of California, Berkeley, is the co-author of the paper.
After the publication of the results, it aroused wide repercussions. Jay Keasling subsequently established Demetrix in California and was authorized from the University of California, Berkeley, to use yeast fermentation technology to produce cannabinoid.
Prospects are promising: the demand for cannabinoid from edible cannabinoid products, medicines and daily chemical products is rising
A variety of cannabinoids have been proved to be of great medical value. The report released by Grand View Research Inc, an international market research company, predicts that the global market value of cannabis for medical use will be as high as $55.8 billion by 2025. At present, THC and CBD are mainly used for medical applications and drug synthesis. There are 306 CBD clinical trials in major countries and organizations around the world. In the future, a large number of safe and stable cannabinoid raw materials will be needed for drug delivery to the market.
In addition, cannabinoid-based food and beverage has become one of the popular trends in North America, and BDS Analytics, a company that studies the cannabis market, has published a report on the edible market of cannabis, which shows that expenditure on cannabis edibility is expected to increase from $1.5 billion in 2018 to $4.1 billion by 2022.
Cannabis skin care is also one of the trends in the future. Jefferies analysts predict that in the next decade, CBD alone will be able to reach $25 billion in beauty products and will account for 15% of the skin care market.
On the other hand, cannabis ban has not been lifted worldwide. Planting and production are still under supervision. How to solve the legislative problems and shortage of raw materials, perhaps biosynthesis is a good way.
At present, there are more than 130 cannabinoids, of which only about five or six have been studied. The content of cannabinoids in hemp flowers and leaves is only 0.1%, 0.01%, or even 0.001%, so the cost of extraction can be as high as 100,000-350,000 US dollars per kilogram.
Cannabinoid synthesis by yeast will greatly reduce the cost of synthesis and expand cannabinoid production capacity. In February, when Jay Keasling’s team published their paper, yeast cannabinoid production was THC 8 mg/l and CBD less than 8 mg/l, but now the company’s production has increased by several orders of magnitude. Jeff Ubersax, chief executive of Demetrix, said the company would continue to expand production to 2,000 to 20,000 litres by 2020.
Is there any other correlation between Li Ka-shing’s two investments in Demetrix?
In September 2017, Jay Keasling collaborated with Shenzhen Advanced Institute to establish a laboratory of synthetic biology.
Following the release of the results of the Jay Keasling team in February this year, the Jay Keasling team signed an agreement with a domestic biotechnology enterprise in Shenzhen Advanced College. The two sides will invest tens of millions of dollars to establish a joint laboratory. As for which company, whether it cooperates with biosynthetic cannabinoids has not been disclosed, but is it Demetrix’s first opportunity to attract Li Ka-shing’s investment?
In addition, many Chinese researchers have participated in the research of cannabinoid synthesis.
If we are careful, we will find that besides this project, many Chinese enterprises and research institutes have participated in the research of synthetic cannabis project.
We have previously reported that ICC International tobacco Corp. has completed its $1.2 million strategic investment in Biotii Technologies Corp., a private biotechnology company in Boston, Massachusetts. Biotii is also a company that synthesizes cannabinoids genetically, and its news reveals that Biotii has established an important partnership with leading medical research institutions in China. The Biotii Leadership Team also includes a Chinese, labeled as a graduate student of Xiamen University and co-founder of a government-funded start-up company.
This also shows that China has entered the field of biosynthetic cannabinoid early and is expected to become a strong player in this field. Whether it can truly achieve commercial production depends not only on technology, but also on the legislative environment. At present, there is no clear statement about the synthesis of cannabinoid at home and abroad, and wait and see.
Like with medical marijuana, the wonderful world of CBD can be slightly overwhelming for a newbie and with the mainstream media going crazy for its health benefits, more and more companies are popping up selling a variety of different CBD products, such as CBD vape, the vape pen, capsules, CBD gummies, and other CBD edibles, CBD isolate, a CBD tincture or two, and even CBD dog treats. With so much information (and misinformation) flying around the Internet and through word of mouth, many of those who are curious about experiencing the benefits of nature’s miracle supplement are finding themselves confused about what to take and when.
So, in a bid to clarify things and debunk some myths about CBD, or cannabidiol oil, along with the potential effects and benefits of CBD, this guide will tell you everything you need to know about how to get started with buying CBD for the first time. Looking to buy CBD? Read on.
Not All CBD Oil Is Created Equal
The very first thing you need to understand in order to get started with making a CBD purchase is that not all oils will be effective and the effects of CBD will differ. The rise in popularity with regards to CBD products means that every day, new CBD companies are popping up left, right, and center and, unfortunately, many of them offer poor quality oils at extortionate prices. You should always look for the following criteria before making a decision about which brand to purchase.
Full spectrum CBD not isolate
Organic-, GMO-, and pesticide-free
CO2 extraction method for purity
Transparency with regards to ingredients and concentrate
Third-party lab tested
The company is willing to provide a lab report on request
Legal amount of THC
Buying a full spectrum oil means that you will also be able to enjoy all of the benefits from the whole plant and not just the isolated cannabinoid compound.
Don’t Be a Penny Pincher
Absolutely everyone loves a bargain in life and, most often, if someone knows they can get away with cutting corners to save money to buy CBD oil in tincture form, they will! This is absolutely fine when it comes to superficial products, but not when it comes to a product that we ingest into our bodies. Trying to save money by buying CBD oil that is way cheaper than other brands is pretty much the same as setting fire to the total amount you will be paying. Producing a pure, full spectrum CBD oil that is extracted in the purest way is expensive, which is why many of the reputable CBD manufacturers charge a higher price for their products. If you purchase premium quality oil from a reputable vendor, you might pay a higher price, but you will also be safe in the knowledge that the positive benefits are in sight.
One Size Doesn’t Fit All
Each and every one of us has a completely unique endocannabinoid system and the efficacy of a particular dose of CBD depends on the following factors:
Severity of your condition
This means that two drops of CBD oil might work really well for some people, but won’t even touch the sides with others. As it stands, the dosage is one of the biggest hurdles that cause new CBD users to become frustrated or give up in favor of pharmaceuticals. Before purchasing CBD oil, consider how serious your symptoms are and how you usually respond to medication. If you usually need a higher dose to feel an effect, then you might need to gradually increase your dose of CBD to several drops each day, in which case buying a bigger sized bottle could end up saving you money in the long run.
Do Your Research
And, by that, we mean Google should become your best friend until you make a decision about which CBD oil to purchase. A simple search of “most reputable CBD companies in your area” should produce a list of rated and reviewed companies. And the great thing about the Internet is that you cannot hide from it. This means that a genuine company will have received reputable reviews and a company offering poor products will also be ousted. A good quality CBD brand will have received media praise as well as recommendations from users online.
If in Doubt, Ask!
2019 has seen a rise in small businesses, especially within the CBD industry. Many of the companies offering CBD oil online will happily take the time to clear up any questions you might have and the better websites will offer an in-depth FAQ section.
Check the THC Levels
One of the common myths about CBD oil is that it will get you high. This is categorically not true and here’s why:
The Cannabis or hemp plant is made up of hundreds of compounds, the two primary ones being CBD and THC. THC is the compound that gets you high and it is only found in incredibly limited quantities in full spectrum oil. Legally, there cannot be more than 0.3% THC in CBD oil and this tiny amount will not produce any psychoactive effects when combined with CBD. If you live in a state where marijuana has been legalized, then it is possible that some dispensaries will sell oils containing a higher amount of THC. If in doubt, always check before making a purchase and, in any case, this information should be prominent on the packing of the product you want to buy.
The power of word of mouth goes a long way, especially when it comes to “hot topics” like CBD. Thanks to the Internet and public forums, scam artists are quickly exposed. In turn, good products will receive praise from consumers, media outlets, and, of course, social media. Spending some time browsing the Internet for CBD oil recommendations makes navigating the confusion you might be experiencing much easier and on finding a brand you feel confident about, a quick Google search on their company name will reveal everything you need to know about their products.
This article is originally published at SundayScaries.